Overview
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites. The current study will determine whether or not the addition of anti-inflammatory diet improves the clinical outcomes in participants with Osteoarthritis, and the role of microbiome and circulating metabolites.
Eligibility
Inclusion Criteria:
- Unilateral radiographic symptomatic KOA
- No changes in therapy during the previous 3 months
- Interested in dietary intervention and able to provide consent and attend follow-up visits
Exclusion Criteria:
- Previous knee surgery
- Severe radiographic disease (KL grade 4)
- Rheumatoid Arthritis
- Any Abnormal blood values in the comprehensive metabolic panel test at screen (Abnormality will be defined based on standard reference ranges)
- Use of corticosteroids and/or intra-articular injections during the preceding 3 months
- Use of fish oils and glucosamine
- Participation in a weight loss program in the preceding 6 months
- Recent changes in physical activity levels
- Regular smoking
- Patients with food allergies
- Patient with other medical conditions that will impair the ability to participate in a nutritional study
- Plan to change systemic therapy
- Patients unwilling to change dietary habits