Overview
The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities. The investigators are interested in learning more about brain activity during everyday decision-making and how everyday decision-making relates to a variety of daily experiences. Examples of everyday decisions include deciding which product to buy, deciding what to eat for a snack, and deciding how to spend free time.
Eligibility
INCLUSION CRITERIA:
Inclusion Criteria for All Participants:
- Normal or corrected to normal vision and hearing
- Verbal and written fluency in English
- Right-handed
- Body mass index of 20-35 kg/m^2
Additional Inclusion Criteria for Participants with Binge-Eating Disorder:
• DSM-5 binge-eating disorder
EXCLUSION CRITERIA:
Exclusion Criteria for All Participants:
- Impaired cognition or other neurological/cognitive problems
- Contraindications to MRI (e.g., certain metal implants, claustrophobia)
- Currently/recently/potentially pregnant, seeking to become pregnant in the near future, or breastfeeding
- Serious and/or unstable medical diseases and conditions, and certain other medical diseases and conditions
- Recent low weight
- Certain medications (e.g., insulin)
- Current/recent frequent recreational drug use, or history of frequent recreational drug use in early adolescence
- Extreme dietary limitations (e.g., veganism), pervasive food allergies, or limited exposure to popular snack foods
- Current/recent suicidality
- Current/recent changes in treatment for mental illness
- Study-relevant research experience
Additional Exclusion Criteria for Comparison Participants:
- Personal history of eating disorders or recurrent binge eating
- Personal history of any other mental illness, including serious substance use problems
- First-degree relative with current or past eating or psychotic disorder
- Significant recent change in weight
Additional Exclusion Criteria for Participants with Binge-Eating Disorder:
- Severe mental illness (e.g., psychotic disorder, severe agoraphobia)
- Certain other current/recent mental illness, including severe substance use problems, that would limit study participation or safety
- Recent anorexia nervosa spectrum disorder, avoidant-restrictive food intake disorder, or bulimia nervosa spectrum disorder