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Bariatric Surgery and Pharmacokinetics of Ramipril

Bariatric Surgery and Pharmacokinetics of Ramipril

Recruiting
18-70 years
All
Phase N/A
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Overview

Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study we investigate the pharmacokinetic effects of bariatric surgery on ramipril.

Eligibility

Inclusion Criteria:

  • Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
  • Being a Norwegian citizen

Exclusion Criteria:

  • Having previously undergone resections in the GI-tract

Study details
    Obesity
    Morbid

NCT03440177

Norwegian University of Science and Technology

26 January 2024

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