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Imaging of Retinochoroidal Vasculature in Patients Being Assessed for Cardiovascular Disease

Imaging of Retinochoroidal Vasculature in Patients Being Assessed for Cardiovascular Disease

Recruiting
18-80 years
All
Phase N/A

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Overview

This study aims to determine whether changes in retinal vasculature seen on SS-OCTA can be correlated to degree of cardiovascular disease as measured by carotid duplex ultrasonography.

Description

The study's primary objective is to determine whether measures taken from SS-OCTA, color fundus photography, and retinal exams can correlate with and predict the presence/degree of carotid occlusive disease as determined by carotid duplex ultrasonography by examining the following parameters: retinal vessel caliber, retinal vessel density, retinal vessel perfusion, retinal vessel tortuosity, presence of Hollenhorst or other plaques, and/or areas of ischemia.

Eligibility

Inclusion Criteria:

  • Subjects between 18 and 80 years of age.
  • No known prior history of retinal disease.
  • Able to participate in a clinical eye examination setting.
  • Able to consent.
  • Subjects receiving standard of care carotid duplex ultrasounds.

Exclusion Criteria:

  • Known ophthalmologic disease (e.g. glaucoma, macular degeneration, ocular injury) other than corrected refractive error.
  • Lack of capacity to provide informed consent.
  • Subjects younger than 18 years of age or older than 80 years of age.
  • History of stroke or acute loss of vision.
  • Unable to participate in a clinical eye examination setting.

Study details
    Cardiovascular Diseases
    Retina; Change

NCT05082402

Northwestern University

14 October 2025

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