Overview
Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations.
To reduce the need for invasive stereoelectroencephalography (SEEG) explorations, electrophysiological and imaging methods have been developed, such as resting-state functional MRI (fMRI) coupled with electroencephalogram and arterial spin-labeling perfusion MRI (ASL-MRI).
It has been published that these new methods enable precise delineation of the epileptogenic zone and better preparation for surgery.
The aim is to determine whether, in children with focal lesional epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG enables precise identification of the epileptogenic zone to be defined by SEEG, the current reference examination.
Eligibility
Inclusion Criteria:
- Be under 18 years of age on the day of inclusion.
- Present with one of the following forms of epilepsy:
- refractory focal lesional epilepsy
- rare non-lesional epilepsy
- Present abnormalities (spikes) on the intercritical EEG
- Have been selected by the "Epilepsy" multidisciplinary staff.
- In the case of refractory lesional epilepsy, be required to perform an EEG-video recording using intracranial electrodes (SEEG) as part of the pre-surgical workup.
- Be affiliated to a health insurance scheme.
Exclusion Criteria:
- Requiring general anesthesia for MRI
- Require sedation specifically for research
- Have generalized epilepsy
- Be deprived of liberty or under guardianship.