Overview
The aim of this multicenter, prospective, randomized, double-blind and large sample study is to explore the preventive effect of low-dose droperidol on POD in elderly patients after non-cardiac surgery, providing new approach for reducing the incidence of POD and improving the prognosis and quality of life.
Eligibility
Inclusion Criteria:
- Age≥65 years
- American Society of Anesthesiologists (ASA): I-III
- Planning to undergo elective non-cardiac surgery under general anesthesia with endotracheal intubation, including digestive, orthopedic, urologic and gynecological surgery
- Estimated operation time more than 2 hours
- Not expected to be admitted to ICU postoperatively
- Proficient in Chinese
- Informed consent
Exclusion Criteria:
- Morbid obesity with BMI >35 kg/m2;
- History of psychological and neurological diseases, such as depression, schizophrenia, epilepsy, severe central nervous system depression, Parkinson's disease, Alzheimer's disease, myasthenia gravis, basal ganglia disease, etc;
- Corrected QT (QTc) of electrocardiogram> 500ms;
- Preoperative liver insufficiency (Child Pugh grade C);
- End-stage renal disease requiring dialysis;
- Severe heart failure [Metablic equivalent (METs)<4];
- Allergic to droperidol;
- Inability to communicate due to coma or dementia in preoperative period;
- Preoperative delirium, assessed by 3D-CAM;
- More than three standard alcoholic drinks per day (≈10 g alcohol , equivalent to 50 g of strong Chinese spirits);
- Participating in conflicting clinical trials;
- Expected to have an additional operation within 7 days after the index operation.