Overview
Narrow band imaging(NBI) could improve the detection of colorectal lesions, previous investigations demonstrated its potential in detecting not only colorectal adenoma but non-adenomatous polyps, including sessile serrated lesions. But no randomized controlled trials with NBI versus white light imaging(WLI) have been conducted to give a definitive conclusion with statistically significant differences. Therefore, we performed a multicenter, prospective, back to back, randomized controlled trial to compare sessile serrated lesions detection and miss rate of withdraw by NBI and WLI in colonoscopy.
Eligibility
Inclusion Criteria:
- Patients whose age are between 45-85
- Patients who have indications for screening
- Patients who have signed inform consent form.
Exclusion Criteria:
- Patients who have undergone colonic resection
- Patients with alarming signs and symptoms of colorectal cancer: hematochezia, melena, anemia, weight loss, abdominal mass, positive digital rectal examination
- Patients with highly suspected or confirmed colorectal cancers by radiographic and laboratory tests
- Patients with abnormal blood coagulation or taking antiplatelets or anticoagulants within 7 days before colonoscopy
- Patients with inflammatory bowel diseases
- Patients with hereditary colorectal cancer syndrome (including familial adenomatous polyposis).
- Patients with pregnancy, severe chronic cardiopulmonary and renal disease.
- Patients with therapeutic colonoscopy for existing lesions
- Patients with failed cecal intubation
- Patients with poor bowel preparation quality that necessitated a second bowel preparation
- Patients refusing to participate or to provide informed consent