Overview

A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration

Eligibility

Inclusion Criteria: Eyes are eligible to be included in the study only if all of the

        following criteria apply. Ocular-specific inclusion criteria apply to the treated eye(s),
        unless otherwise specified.
          -  Eyes that are naive to treatment with pegcetacoplan that are prescribed pegcetacoplan
             per routine clinical practice according to approved pegcetacoplan prescribing
             information (ie, the clinical decision to treat with pegcetacoplan must be made before
             study participation is discussed with the patient)
          -  Patient age ≥60 years
          -  Visual acuity better than 20/200 on Snellen chart
          -  Clinical diagnosis of GA of the macula secondary to AMD in one or both eyes as
             determined by the investigator using OCT and/or FAF imaging
          -  GA lesion meeting the following criteria as determined by the investigator's
             assessment of Spectralis OCT and/or FAF images at screening:
               1. Nonsubfoveal lesion(s)
               2. GA lesion visualized in its entirety on the macula-centered OCT image and not
                  contiguous with any areas of peripapillary atrophy
               3. Presence of any pattern of hyperautofluorescence in the junctional zone of GA;
                  absence of hyperautofluorescence (ie, pattern = none) exclusionary
          -  Adequate clarity of ocular media and adequate pupillary dilation and fixation to
             permit the collection of good quality images as determined by the investigator
          -  Patient willing and able to give informed consent and to comply with the study
             procedures and assessments
        Exclusion Criteria: Ocular-specific exclusion criteria apply to the study eye(s) only,
        unless otherwise specified.
          -  GA secondary to a condition other than AMD such as Stargardt disease, cone rod
             dystrophy, or toxic maculopathies like Plaquenil maculopathy in either eye
          -  Active, suspected, or history of intraocular inflammation in either eye at screening
             or on day 1
          -  Any history of or active choroidal neovascularization associated with AMD or any other
             cause, including any evidence of retinal pigment epithelial tears or rips in SD OCT
             imaging
          -  Presence of an active ocular disease that in the opinion of the investigator
             compromises or confounds visual function, including but not limited to uveitis and
             other macular diseases (eg, clinically significant epiretinal membrane, full thickness
             macular hole, uncontrolled glaucoma/ocular hypertension). Conditions that in the
             opinion of the investigator are benign, such as peripheral retina dystrophy, are not
             exclusionary
          -  Any prior treatment with anti-VEGF agents
          -  Intraocular surgery (including lens replacement surgery) within 3 months prior to
             screening
          -  History of laser therapy in the macular region
          -  Aphakia or absence of the posterior capsule. Note: Yttrium aluminum garnet laser
             posterior capsulotomy for posterior capsule opacification done at least 60 days prior
             to screening is not exclusionary.
          -  Any ocular condition other than GA secondary to AMD that may require surgery or
             medical intervention during the study period or, in the opinion of the investigator,
             could compromise visual function during the study period
          -  Any contraindication to IVT injection
          -  Current ocular or periocular infection in either eye
          -  Intravitreal medical device placement
          -  Participation in any prior or current systemic experimental treatment within 6 weeks
             or 5 half lives of the active ingredient (whichever is longer) prior to the start of
             study treatment or in any other investigational treatments specific to GA. Clinical
             trials solely involving observation, over-the-counter vitamins, supplements, or diets
             are not exclusionary
          -  Medical or psychiatric conditions that, in the opinion of the investigator, make
             consistent follow-up unlikely or would make the patient an unsafe study candidate
          -  Known hypersensitivity to fluorescein sodium for injection or hypersensitivity to
             pegcetacoplan or any of the excipients in pegcetacoplan solution
          -  History or current use of brolucizumab and/or pharmacological treatments that gain
             approval for the treatment of GA