Overview

: Use of novel radio-pharmaceutical 64CUDOTA-ECL1i to evaluate arterial atherosclrosis

Eligibility

Inclusion Criteria: Normal Volunteers: 18-40 years of age, non smoker, no history of

        diabetes, hypertension, or hyperlipidemia. Patients: 50-89 years of age, adequate
        nutritional status, with or without smoking history, diabetes, hypertension, and
        hyperlipidema. Both asymptomatic and symptomatic patients with known carotid artery
        atherosclrosis >70% and scheduled to undergo surgery. Advanced peripheral artery disease.
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        Exclusion Criteria:Inability to receive and sign informed consent. Currently enrolled in
        another study. Patients who have type 1 diabetes or are in septic shock, receiving steroid
        therapy, recent history of heavy alcohol consumption, (male >2 drinks per day, and female >
        1 drink per day. following extreme diets like Atkins or South Beach diet or with Stage 4
        chronic renal failure. Patients with unstable clinical condition that in the opinion of the
        PI precludes participation in the study. Inability to tolerate 60 minutes in a supine
        position with arms down at sides. Contraindications to MR imaging, (pacemaker, brain
        aneurysm clips, shrapnel, etc. Positive pregnancy test or lactating. Have another
        conditions such as cancer or autoimmune/inflammatory diseases, e.g. rheumatoid arthritis or
        multiple sclerosis that are known to have increased expression of CCR2.
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