Overview

This is a retrospective and prospective real-world clinical study of molecular typing in the treatment of advanced thyroid cancer.

The retrospective study : Patients with advanced thyroid cancer who received precise treatment in our hospital from January 2020 to December 2023 were retrieved. The number of previous treatment lines was not limited. Patients who met the inclusion criteria were screened according to the inclusion and exclusion criteria. Demographic information, clinical characteristics, tumor treatment history, medication regimen, adverse reactions, molecular test results, survival follow-up results and other data were collected.

The prospective study : Patients with advanced thyroid cancer who received precise treatment in our hospital from January 2024 to April 2027 were enrolled.

Eligibility

Inclusion Criteria:

1. Patients volunteered to participate in this study and signed informed consent;
2. Age: ≥ 18 years old, male or female;
3. Histologically diagnosed locally advanced or recurrent / metastatic thyroid cancer that cannot undergo radical surgery meets one of the following requirements:
   1. Radioiodine-refractory thyroid cancer;
   2. Differentiated thyroid carcinoma not suitable for iodine therapy;
   3. Medullary thyroid carcinoma;
   4. High-grade or poorly differentiated thyroid cancer;
   5. Anaplastic thyroid cancer;
4. Patients who had undergone NGS testing (in our hospital or other hospitals) were able

   to query the test report or the key genetic test results recorded in the medical history (such as BRAF, RET, NTRK and other genetic test results).

Exclusion Criteria:

1. Patients who are participating in clinical trials of other drugs;
2. There is evidence that the patients are pregnant or lactating;
3. Other situations that are not suitable for inclusion in this study.