Overview

Aim : To assess the ability of healthy subjects and patients with a severe motor disability to voluntary control their attention

Material and Methods:

Population: healthy subjects, patients with brain injury Electroencephalographic study to research attentional modulation during different kind of stimulation (visual, auditory, tactile)

Sudy 1: passive recording.

Study 2: active recording (instruction of attentional control given to the subject).

Study 3: active recording with a feedback obtained after a processing of the brain activity.

Eligibility

Inclusion Criteria:

Inclusion criteria for patients :

• Adults, man or woman, left or right-handed, from 18 years old to 80 years-old ;
• Diagnosis :
  • Locked-in syndrome :

        < Brainstem injury, without any evolution for at least 3 week, etiology : vascular,
        traumatic < Amyotrophic Lateral Sclerosis < Following damage to the central or peripheral
        nervous system
          -  Or Minimal conscious state or Unresponsive Wakefulness Syndrome consecutive to a
             severe acquired brain injury for at least one month
          -  Or with a severe brain injury, since birth or acquired, for at least one month
          -  Or with Guillain-Barré syndrome
               -  Subjects affiliated to social security;
               -  Signature of consent form by the patient or by a relative (family member or "the
                  trusted person") if obtaining a consent is impossible
        Inclusion criteria of Healthy subjects
          -  Adults, man or woman, left or right-handed, from 18 years old to 80 years-old ;
          -  Without known auditory impairment
          -  Subjects able to understand the experimental instructions
          -  Subjects affiliated to social security;
          -  Signature of consent form
        Exclusion criteria of patients and healthy subjects
          -  Medical history : psychiatric disorders (except if due to brain injury), neurologic
             disorders (except if due to brain injury)
          -  For healthy subjects : history of brain injury
          -  Pregnant women or breastfeeding women
          -  Person under legal protection
          -  Medico-legal conflicts
          -  Absence of consent by the subject or the patient or his/her representant