Overview
This is a prospective study aimed at recruiting 30,000 individuals, aged 40-70 years old, and following them longitudinally for 25 years with repeated measurements. The basic follow-up frame will include a visit to the Clinical Test Center (CTC) every two years and a phone interview every other year (on uneven years). Sample collection and biobanking will be performed every two years and online questionnaires will be filled out on an annual basis.
The primary goals are to study the variation observed across different individuals in disease susceptibility, clinical phenotypes, and therapeutic responses. The study aims at studying the complex interplay and relative contribution of different omics, physiological characteristics and lifestyle on disease pathogenesis and progression and to evaluate how these effects are mediated.
Eligibility
Inclusion Criteria:
- Ages 18+, males and females.
Exclusion Criteria:
- Pregnancy.
- Mentally disabled or in general legally non-competent.
- Prisoner or soldier. Soldiers: mandatory service only
- Active cancer
- Fertility Treatments (current)
- Hepatitis ( B, C), chronic or acute
- HIV
- Liver cirrhosis
- Dialysis
- Unstable medical conditions