Overview

The goal of this clinical trial is to evaluate the efficacy and safety of Cadonilimab(AK104) combined with Nab -Paclitaxel as first line therapy for recurrent or metastatic muscle invasive bladder. Eligible participants will receive AK104 (up to 24 months) plus Nab-Paclitaxel (for 6 cycles) until radiologic disease progression, unacceptable toxicity, or withdrawal from the study, whichever occurred first. The primary endpoint is objective response rate.

Eligibility

Inclusion Criteria:

1. Sign a written informed consent form before joining the group.
2. Age>18 years old.
3. Patients with advanced metastatic bladder cancer confirmed histologically or pathologically.
4. Have not received systemic treatment.
5. Have measurable lesions (according to RECIST 1.1 standard, non lymph node lesions have a CT scan length of ≥ 10 mm, and lymph node lesions have a CT scan short diameter of ≥ 15 mm).
6. ECOG PS score: 0-1.
7. The expected survival period is greater than 12 weeks.
8. The functions of important organs meet the following requirements (excluding the use of any blood components and cell growth factors within 14 days):

        (1) Blood routine: Neutrophils ≥ 1.5 × 10^9/L;Platelet count ≥ 100 × 10^9/L;Hemoglobin ≥
        90g/L.
        (2) Liver and kidney function:Serum creatinine (SCr) ≤ 1.5 times the upper limit of normal
        value (ULN) or creatinine clearance rate ≥ 50 ml/min (Cockcroft Fault formula);Liver
        function: Aspartate aminotransferase (AST) ≤ 2.5 x ULN, alanine liver aminotransferase
        (ALT) ≤ 2.5 x ULN in subjects without liver metastasis; ALT and AST<5 x ULN in liver
        metastasis subjects.;Total serum bilirubin (TBIL) ≤ 1.5 x ULN (excluding Gilbert syndrome
        where TBIL<3.0 mg/dL);Urinary protein<2+;If the urine protein is ≥ 2+, the 24-hour urine
        protein quantitative display must be ≤ 1g.
        9. Normal coagulation function, no active bleeding or thrombosis disease
          1. International standardized ratio INR ≤ 1.5 × ULN;
          2. Partial thromboplastin time APTT ≤ 1.5 × ULN;
          3. Prothrombin time PT ≤ 1.5 × ULN. 10. Non surgical sterilization or reproductive age
             female patients are required to use a medically approved contraceptive method (such as
             an intrauterine device, contraceptive pill, or condom) during the study treatment
             period and within 3 months after the end of the study treatment period. Non surgically
             sterilized female patients of childbearing age must have a negative serum or urine HCG
             test within 7 days before enrollment in the study. And it must be non lactating.
        11. The subjects voluntarily joined this study with good compliance, safety, and survival
        follow-up.
        Exclusion Criteria:
          1. The subject has previously or simultaneously suffered from other malignant tumors
             (excluding cured skin basal cell carcinoma and cervical carcinoma in situ).
          2. The subject is known to have previous allergies to macromolecular protein formulations
             or known to be allergic to the drug components used.
          3. The subject has any active autoimmune disease or a history of autoimmune disease (For
             example, but not limited to: autoimmune hepatitis, interstitial pneumonia, uveitis,
             enteritis, hepatitis, pituitary inflammation, vasculitis, nephritis, hyperthyroidism,
             decreased thyroid function, who have undergone thyroid surgery in the past cannot be
             included. subjects with vitiligo or complete remission of childhood asthma, who do not
             require any intervention in adulthood, can be included. subjects who require
             bronchodilators for medical intervention) Asthma cannot be included).
          4. The subject is currently using immunosuppressive agents or systemic or absorbable
             local hormone therapy to achieve immunosuppressive effects (dosage>10mg/day of
             prednisone or other therapeutic hormones), and continues to use them within 2 weeks
             before enrollment.
          5. Ascites or pleural effusion with clinical symptoms require therapeutic puncture or
             drainage.
          6. Patients with clinically uncontrollable cardiac symptoms or diseases, such as: (1)
             NYHA grade 2 or above heart failure, (2) unstable angina pectoris, (3) myocardial
             infarction within 1 year, (4) clinically significant supraventricular or ventricular
             arrhythmias that require treatment or intervention.
          7. The subject has an active infection or an unexplained fever>38.5 degrees Celsius
             during the screening period or before the first administration (according to the
             researcher's judgment, the subject's fever caused by the tumor can be included in the
             group).
          8. Patients with past and current history of pulmonary fibrosis, interstitial pneumonia,
             pneumoconiosis, radiation pneumonia, drug-related pneumonia, and severe impairment of
             lung function with objective evidence.
          9. Subjects have congenital or acquired immune deficiency, such as HIV infected persons,
             or active hepatitis (transaminase does not meet the inclusion criteria, hepatitis B
             reference: HBV DNA ≥ 1000 IU/ml. hepatitis C reference: HCV RNA ≥ 1000 IU/ml). Chronic
             hepatitis B virus carriers with HBV DNA<2000 IU/ml must receive antiviral treatment
             simultaneously during the trial period before they can be enrolled.
         10. Live vaccines may be administered less than 4 weeks before the study medication or
             during the study period.
         11. The subject is known to have a history of psychotropic substance abuse, alcoholism, or
             drug abuse.
         12. Accepted Chinese herbal medicine or traditional Chinese patent medicines and simple
             preparations with anti-tumor indications within 2 weeks before the first
             administration.
         13. The researcher believes that it should be excluded from this study. For example, based
             on the researcher's judgment, the subject may have other factors that may cause the
             study to be terminated midway, such as other serious diseases (including mental
             illness) requiring concurrent treatment, serious laboratory test abnormalities,
             accompanied by family or social factors, which may affect the safety of the subject,
             or the collection of data and samples.