Overview
This is a randomized control, double-blind study in which women who are about to go an elective vaginal hysterectomy are offered to participate.
Patients will be randomly assigned to one of two groups: the tranexamic acid group, in which 1 gram of tranexamic acid (Hexakapron) is administered intravenously before surgery, and the control group, in which patients will receive 10 ml of normal saline 0.9% intravenously.
Description
This is a randomized control, double-blind study in which women who are about to go for an elective vaginal hysterectomy are offered to participate.
Patients will be randomly assigned to one of two groups: the tranexamic acid group, in which 1 gram of tranexamic acid (Hexakapron) is administered intravenously before surgery, and the control group, in which patients will receive 10 ml of normal saline 0.9% intravenously.
A nurse will prepare the solution according to the randomization and will handle it to the anesthesiologist.
Eligibility
Inclusion Criteria:
*Women in general good health (defined as American Society of Anesthesiologists grade 1-2)
who are about to undergo elective vaginal hysterectomy indicated by pelvic organ prolapse
(POP).
Exclusion Criteria:
- allergy to TXA
- familial or personal history of hypercoagulability disorder or thromboembolic events
- impaired renal function or hematuria
- patients receiving antithrombotic therapy
- additional concurrent abdominal/ laparoscopic procedures
- malignancy
- Post-assignment exclusion will be executed in cases of conversion to laparotomy/
laparoscopy.