Overview
The goal of this observational study is to learn about dynamic changes of Torquetenovirus (TTV) load in Chinese renal transplant recipients. The main questions it aims to answer are:
- Is there correlation between TTV load and rejection?
- Is there correlation between TTV load and infection?
- Can changes in the TTV load of kidney transplant recipients predict rejection or infection?
Participants will:
- receive 13 follow-up visits within 1 year after kidney transplantation
- provide 2 ml of whole blood for TTV load testing and other related testing at each follow-up
- provide 10 ml of whole blood for dd-cfDNA testing at four follow-ups (1, 3, 6 and 12 months after transplantation)
- provide 1 ml of serum for donor-specific antibody testing at three follow-ups (1, 6 and 12 months after transplantation)
Eligibility
Inclusion Criteria:
- Receiving ABO compatible renal allotransplantation from the initiation of the study to December 31, 2023
- Receiving tacrolimus /mycophenolate mofetil(or mycophenolic acid)/prednisone as maintenance immunosuppression after renal transplantation
- Receiving universal prophylaxis for CMV infection and PJP infection
Exclusion Criteria:
- Receiving combined liver-kidney, pancreas-kidney or heart-kidney transplantation
- Recipients with active hepatitis B or hepatitis C infection
- Recipients with anticipated irregular follow-up