Overview
Prospective multicenter cohort to determine patient profiles (associated factors, including allodynia) with a better response to pain desensitization by capsaicin delivered in the form of a high concentration patch (8%), in a population of patients with peripheral neuropathic pain and followed up in a pain consultation in the Auvergne Rhône Alpes region.
Eligibility
Inclusion Criteria:
- Patient over 18 years of age on the day of inclusion
- Patient who has been informed and has not expressed opposition to participating in the study,
- Patient with peripheral neuropathic pain (whatever the etiology), defined by :
- "Neuropathic Pain 4" score ("DN4" score) ≥ 4/10
- AND pain according to the numerical scale (EN) > 4/10,
- AND stable analgesic treatment for at least 1 month,
- AND with or without mechanical allodynia according to the Quantitative Sensory Testing (QST) : Brush test (dynamic), Von Frey test (static)
- AND with or without thermal allodynia to hot or cold as determined by a ROLLTEMP-II® (Rolltemp is a device designed for quick screening of temperature sensibility over large body areas).
- Patient responding to an indication of desensitization to high concentration capsaicin
concentration and not presenting any contra-indication.
- Patient naïve of high concentration of Capsaicin on the concerned zone
- Patient understanding French
Non-inclusion Criteria:
- Patient with pain related to complex regional pain syndrome (criteria not meeting the indication for capsaicin)
- Patient with active cancer (underlying disease and treatments may modify pain perception),
- Patient receiving or having received in the last 3 months Botulinum toxin A on the concerned area (this treatment of neuropathic pain may modulate the effect of capsaicin and disturb the demonstration of causality),
- Patient with planned surgery within the next 12 months on the painful site (surgery may cause neuropathic damage and/or bias the pain assessment),
- Patient included in an interventional research protocol,
- Patient under guardianship or curators,
- Patient under legal protection
Exclusion Criteria:
None