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Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity

Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity

Recruiting
30-70 years
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.

Eligibility

Inclusion Criteria:

  • Undergoing gastric bypass surgery
  • Confirmed AUROC F=0 or F>2 liver fibrosis
  • Age 30-70 years
  • BMI greater than 40 kg/m2
  • Negative pregnancy test (female only)
  • Lab Values: Normal TSH

Exclusion Criteria:

  • Autoimmune diseases
  • Hepatitis B or C positive
  • Heavy alcohol use
  • Active smoking history
  • Active cancer history
  • History of asthma
  • History of COPD
  • Taking Plavix or Coumadin
  • Blood donation within past 2 months
  • Glucocorticoid Therapy
  • Taking antihistamine on regular basis

Study details
    Obesity
    Morbid
    NASH - Nonalcoholic Steatohepatitis
    Chronic Inflammation

NCT04232566

Mayo Clinic

16 May 2024

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FAQs

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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