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Cellular Scale Measures of Short-Term Retinal Atrophy Progression

Cellular Scale Measures of Short-Term Retinal Atrophy Progression

Recruiting
18-70 years
All
Phase N/A
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Overview

Our goal is to determine the cellular scale changes that occur in subjects who have disease progression due to pentosan polysulfate sodium toxicity

Description

The aim of this study is to determine the formation and progression of retinal changes caused by pentosan polysulfate sodium toxicity. To do this, we will measure how single cone photoreceptors respond to light in regions of the retina that are affected by pentosan polysulfate sodium toxicity. We will also measure how the retinal pigment epithelium, a layer of cells vital to photoreceptor health, change in shape and size over time.

Eligibility

Inclusion Criteria:

  • A history of pentosan polysulfate sodium (Elmiron) usage for 5+ years
  • Documented retinal findings that are associated with pentosan polysulfate sodium toxicity

Exclusion Criteria:

  • Presence of cataract or ocular media opacity that impedes retinal imaging
  • If standard pupil dilation imposes a risk to ocular health
  • Documented severe dry eye on ocular exam
  • High refractive error (more than -/+ 6 Diopters)

Study details
    Pentosan Polysulfate Sodium Maculopathy
    Pigmentary Maculopathy
    Toxic Maculopathy
    Pigmentary Retinopathy
    Interstitial Cystitis
    Chronic

NCT05643157

Indiana University

26 January 2024

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