Overview

This longitudinal, prospective, multicentre study is to monitor lung function prospectively in childhood cancer patients after diagnosis. The impact of cancer treatment on pulmonary dysfunction non-invasively using lung function, lung imaging and breath analysis as well as clinical symptoms using a questionnaire will be assessed at different time points.

Eligibility

Inclusion Criteria:

• at least one of the following cancer treatments:
  • chest radiation
  • treatment with any kind of chemotherapy
  • hematopoietic stem cell transplantation (HSCT)
  • thoracic surgery
• consent for Childhood Cancer Registry (ChCR) registration

Exclusion Criteria:

• no signed informed consent
• Operation outside the chest area as only cancer treatment
• Relapsed cancer (patients who develop relapse during the study will not be excluded)
• In addition for MRI and lung function tests:
  • Subjects who are respiratory insufficient and cannot perform a lung function test (less than 92% O2 saturation; under O2 therapy)
  • Pregnant
  • MRI measurement not possible without sedation
  • Metal (e.g. pacemaker) in the body