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A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle

Recruiting
18 years and older
All
Phase 4
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.

Eligibility

Inclusion Criteria:

  • Adult male and female patients undergoing lower extremity orthopedic surgery at the study institutions (St. Mary Hospital and Rochester Methodist Hospital within the Mayo Clinic Rochester hospital system).

Exclusion Criteria:

  • Patients who refuse research participation.
  • Patients who are pregnant.
  • Patients with known pulmonary pathology (COPD, asthma requiring routine treatment).

Study details
    Respiratory Function Loss
    Respiratory Complication

NCT05856136

Mayo Clinic

1 November 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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