Overview

This study is a single-arm, multicenter clinical study to evaluate the efficacy and safety of SBRT combined with cardonilizumab and lenvastinib in the treatment of unresectable hepatocellular carcinoma with portal vein tumor thrombus

Eligibility

Inclusion Criteria:

1. Age: 18-70 years old;
2. Eastern Cooperative Oncology Group (ECOG) -Performance Status(PS):0-2 points；
3. Hepatocellular carcinoma was diagnosed according to histopathology or the 2022 diagnostic criteria for primary liver cancer；
4. Expected survival period≥3 months;
5. Liver function grade Child-Pugh A or better grade B (7 points);
6. At least one measurable lesion:

   Liver lesion ① The Lesion can be accurately measured at least in the range of 1.0cm;

   ② The Lesion is suitable for repeated measurement;

   • The lesion shows enhanced intratumoral arteries on computed tomography (CT) or magnetic resonance imaging (MRI); Non-liver lesion In at least one dimension, the short axis of lymphadenopathy (LN) is≥1.5cm. Longest diameter of non-nodular lesions is≥1.0cm
7. The Barcelona liver cancer staging system is stage C (BCLC-C), which meets one of the

   following conditions:

        (1) Liver tumor can be resected, which is combined with Vp 3-4 portal vein cancer thrombus;
        (2) Liver tumor is unresectable or has distant metastasis, and is combined with Vp1-4 type
        portal vein cancer thrombus; 8. The patient had not received prior systemic therapy
        including sorafenib, lenvatinib, chemotherapy; 9. The patient had previously received
        locoregional therapy (including radiofrequency or ablation therapy, percutaneous ethanol or
        acetic acid injection, cryotherapy, high intensity focused ultrasound, hepatic artery
        chemoembolization, hepatic artery embolization, etc., and the local treatment area had
        definite progression (according to RECIST v1.1 criteria); 10. Baseline blood routine and
        biochemical indicators meet the following criteria: Hemoglobin≥90g / L; Absolute neutrophil
        count (ANC)≥1.5× 10 ^ 9 / L; Platelet≥75×10 ^ 9 / L; ALT,AST ≤3×upper normal value (ULN);
        Serum total bilirubin ≤ 1.5 ×ULN; Serum creatinine ≤1.5 × ULN; Serum albumin was used
        for≥30g / L.
        Exclusion Criteria:
          1. Patients diagnosed with hepatobiliary duct cell carcinoma, mixed cell carcinoma, or
             fibrolaminar cell carcinoma；
          2. Patients with a history of allogeneic organ transplantation or allogeneic
             hematopoietic stem cell transplantation or planned transplantation；
          3. Patients have hepatic encephalopathy (West Haven Standard Grade III, Level IV) or have
             moderate or severe ascites (i.e., patients requiring therapeutic puncture drainage) or
             have uncontrolled pleural or pericardial effusion；
          4. Patients have symptomatic, untreated, or progressive central nervous system (CNS) or
             leptomeningeal metastases.If all the following criteria are met, asymptomatic subjects
             with treated CNS lesions can be enrolled.