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Acute Pharmacokinetic-pharmacodynamic Change of Rocuronium After Reperfusion of Renal Graft

Acute Pharmacokinetic-pharmacodynamic Change of Rocuronium After Reperfusion of Renal Graft

Recruiting
18-60 years
All
Phase N/A
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Overview

Reperfusion of renal graft in kidney transplantation can change the pharmacokinetic-pharmacodynamic (PKPD) parameters of rocuronium. The immediate increase of urine output during surgery may change the PKPD parameters of the drugs, including elimination rate. The goal of this study is to characterize the PKPD model of rocuronium during kidney transplantation and establish a basis for adequate dosage of rocuronium in kidney transplantation.

Through PKPD modeling, the changes during reperfusion of the renal graft will be evaluated. Furthermore, the factors related to the changes will be assessed. Adjusting the infusion rate according to the step of kidney transplantation will lead to stable muscle relaxation and fast recovery.

Eligibility

Inclusion Criteria:

  • patients scheduled for elective living donor kidney transplantation
  • end stage renal disease with oliguria or anuria
  • normal BMI (BMI 18.5 ~ 25)
  • obtained informed consent

Exclusion Criteria:

  • patient with underlying neuromuscular disease

Study details
    End Stage Renal Disease
    Transplantation

NCT02827435

Seoul National University Hospital

26 January 2024

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