Overview

To evaluate the pathological complete response rate (pCR) of nivolumab combined with SOX (oxaliplatin + S-1) for neoadjuvant therapy of resectable gastric and gastroesophageal junction adenocarcinoma;

Eligibility

Inclusion Criteria:

Patients must meet all of the following inclusion criteria to be enrolled in the study:

1. Patients voluntarily participate in the study and sign the informed consent form; 2. Age ≥ 18 years and ≤ 75 years; 3. Have pathologically confirmed gastric adenocarcinoma or gastroesophageal junction adenocarcinoma; 4. Patients with gastric or gastroesophageal junction adenocarcinoma at the clinical staging of cT3-4 or N+, M0 (staging according to AJCC version 8) who could be radically resected as determined by CT and laparoscopy; 5. Have not received anti-tumor therapy (such as surgery, radiotherapy, chemotherapy, targeted therapy, immunotherapy, etc.); 6. Planned surgical treatment after completion of neoadjuvant therapy; 7. Able to swallow tablets normally; 8. ECOG score 0-1; 9. Expected survival >=12 months; 10. Main organ functions normal, i.e., meeting the criteria below:
   1. Blood routine examination criteria shall meet:

      (No blood transfusion or blood products within 14 days, no G-CSF or other hematopoietic stimulating factors are used for correction) Absolute neutrophil count ≥1.5×109/L; Platelet ≥80×109/L; Hemoglobin ≥ 80 g/L

   2. Criteria for biochemical tests:

Total bilirubin <1.5×ULN; ALT and AST≤2.5×ULN;

        Serum Cr ≤ 1.5 × ULN or endogenous creatinine clearance > 50 ml/min (males: Endogenous
        creatinine clearance rate = ((140-age) × body weight)/(72 × serum Cr); female: endogenous
        creatinine clearance rate = ((140-age) × body weight)/(72 × serum Cr) × 0.85; body weight
        unit: kg; serum Cr unit: mg/mL):
        11. Female subjects of childbearing potential must have a negative serum pregnancy test
        within 7 days prior to the first dose and be willing to use a highly effective method of
        contraception during the trial and for 120 days after the last dose. Male subjects with
        partners of childbearing potential should be surgically sterilized or agree to use highly
        effective methods of contraception during the trial and for 120 days after the last dose;
        Exclusion Criteria:
        Patients with any of the following are not to be enrolled in the study:
          1. Patients with unresectable factors, including unresectable tumor causes or
             unresectable surgical contraindications or refusal of surgery;
          2. Previous or concurrent other malignancy;
          3. Suffering from any chronic or major illness considered intolerable to treatment (eg,
             severe cardiac disease, uncontrolled hypertension, some degree of hepatic or renal
             dysfunction, etc.)
          4. Patients who have previous gastrointestinal perforation, abdominal abscess or recent
             (within 3 months) intestinal obstruction or imaging and clinical symptoms suggestive
             of intestinal obstruction;
          5. Patients having clinically significant bleeding symptoms or definite bleeding tendency
             within 3 months before the first dose of study drug, such as gastrointestinal
             bleeding, hemorrhagic gastric ulcer or suffering from vasculitis; if stool occult
             blood is positive at baseline, reexamination may be performed; if stool occult blood
             remains positive after reexamination, gastroscopy is required (except for patients
             having gastroscopy within 3 months before enrollment to exclude such condition);
          6. Patients in the active stage of infection requiring treatment (such as antibacterial
             drugs, antiviral drugs, antifungal drugs);
          7. Active hepatitis (hepatitis B reference: HBsAg positive and HBV DNA ≥ 500 IU/ml;
             hepatitis C reference: HCV antibody positive and HCV viral copy number > upper limit
             of normal);
          8. Patients with congenital or acquired immunodeficiency (such as HIV infection);
          9. Patients with any active autoimmune disease or history of autoimmune disease with
             potential relapse;
         10. Planned or previous organ or allogeneic bone marrow transplant;
         11. Patients with current interstitial pneumonia or interstitial lung disease, or previous
             history of interstitial pneumonia or interstitial lung disease requiring steroids, or
             subjects with active pneumonia or severe lung function impairment on screening CT;
             active pulmonary tuberculosis;
         12. Ongoing or recent treatment with immunosuppressive drugs or systemic corticosteroids
             to achieve immunosuppression;
         13. Patients who have received a live attenuated vaccine within 28 days prior to the first
             dose of study drug or who require administration of such vaccine during treatment or
             within 60 days after the last dose;
         14. Patients with known hypersensitivity to any of the study drugs or any of their
             excipients;
         15. Nursing mothers;
         16. Any factors that, in the judgment of the investigator, could affect patient safety and
             force the termination of the study