Overview
The aim of this study is to evaluate the effectiveness of caffeine versus probiotics supplementation as adjuvant therapy for preterm neonates with Bronchopulmonary dysplasia (BPD).
Eligibility
Inclusion Criteria:
- Male and female preterm neonates less than 37 weeks gestational age.
- Suffering from Bronchopulmonary dysplasia (BPD) diagnosed as follow:
- History: Preterm infant with persistence oxygen dependency up to 28 days of life.
- Clinical signs: increase work of breathing, increase oxygen requirements , increase in apnea , bradycardia and retraction.
- Laboratory: arterial blood gases and electrolytes.
- Radiology: streaky interstitial markings, patchy atelectasis , intermingled with cystic areas and severe lung hyperinflation.
Exclusion Criteria:
- Term and post term neonates
- Neonates with congenital infections
- Neonates with major congenital anomalies