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Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

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Overview

This research trial studies whole exome sequencing in finding causative variants in germline deoxyribonucleic acid (DNA) samples from patients with hypertension receiving bevacizumab for breast cancer. Studying samples of germline DNA in the laboratory from patients with hypertension receiving bevacizumab for breast cancer may help doctors learn about changes that occur in DNA and identify biomarkers related to hypertension.

Description

PRIMARY OBJECTIVES:

I. To identify, using next generation sequencing, rare variants of large effect size that impact the risk of hypertension in patients from the clinical trial Eastern Cooperative Oncology Group (ECOG)-5103 (E5103).

OUTLINE

Previously collected germline DNA samples are analyzed via whole exome sequencing.

Eligibility

Inclusion Criteria:

  • European American patients with deoxyribonucleic acid (DNA) available and designated case or control
  • Patients who developed grade 3-4 bevacizumab-induced hypertension during their treatment with bevacizumab
  • Patients who did not develop hypertension following a full course of treatment with bevacizumab

Study details
    Breast Carcinoma

NCT02610413

National Cancer Institute (NCI)

10 July 2025

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