Overview
Randomized, investigator-blinded, controlled, multicenter comparative study on the treatment of acute head lice infestation in children with 2 dimeticone preparations with different application times and compositions: Dimet 5® (100% dimeticone) versus Hedrin® Once Liquid Gel (4% dimeticone + nerolidol) with treatment success assessment via freedom from infestation of live head lice at final examination at V2, i.e. day 19 after first treatment.
Eligibility
Inclusion Criteria:
- Acute head lice infestation
- Age ≥ 6 months
- Adequate informed consent for study participation:
- Age-appropriate informed consent and verbal informed consent from the patient (if capable of both).
- Written informed consent from the legal guardian(s) (written and verbal).
Exclusion Criteria:
- Adults (≥ 18 years of age)
- Known hypersensitivity to any component of the test or comparator product.
- Scalp lice therapy in the previous 2 weeks (with an appropriate drug or medical device).
- Severe disease of the scalp or injuries/open wounds on the hairy head
- Secondary infection in the area of the hairy head
- Treatment with cotrimoxazole or trimethoprim in the last 4 weeks or new treatment to be initiated now
- Other relevant reasons, e.g. diseases or dysfunctions, which, in the opinion of the investigator, militate against the inclusion of the patient in the study (including risk factors for severe COVID-19 disease in the case of SARS-CoV-2 infection)
- Simultaneous participation of another household member in the trial.
- Previous participation in this trial
- Participation in another trial within the last 30 days
- Inability of the legal guardian(s) to understand the study content and instructions.
- Limited legal capacity of the legal guardian(s)
- Apparent unreliability or unwillingness to cooperate on the part of the legal guardian(s)
- Known alcohol, medication or drug dependency of the legal guardian(s)
- Dependence of the patient or guardian on the sponsor or investigator.