Overview
The hypothesis of the study is that non-invasive Single photon emission computed tomography (SPECT-CT) bone scintigraphy makes it possible to better characterize solitary bone lesions, in particular the exclusion of their malignancy in order to avoid unnecessary biopsy and possible complications for the patient.
Description
Bone scintigraphy includes 3 stages: study of perfusion then of early tissue uptake and finally of late bone fixation.
Hyperactivity of malignant bone lesions at the 3 stages of bone scintigraphy has been reported, but on planar scintigraphic images not allowing precise anatomical localization of the lesions.
Currently, the generalization of SPECT-CT (Single Photon Emission Computed Tomography) combined with Tomodensitometry) acquisition thanks to the deployment of semiconductor cameras, makes it possible to carry out a multiparametric analysis of bone lesions with quantification of the intensity of the signal expressed in SUVmax (Standard Uptake Value maximum) at the 3 times of the scintigraphy
Eligibility
Inclusion Criteria:
- Person, having received complete information on the organization of the research and
having signed the informed consent and:
- Age ≥ 18 years old.
- Having read and understood the information document.
- Affiliated to a social security scheme.
- Patient with an indeterminate solitary bone lesion on conventional imaging, for
which an indication for biopsy +/- excision is planned.
Exclusion Criteria:
- Pregnant woman or woman of childbearing age and without contraceptive means or nursing mother.
- Unstable medical condition and/or inability to remain still during recordings.
- Known allergy to one of the components of the radiopharmaceutical technetium-99m-Technescan HDP (product required to perform the bone scan).
- Person referred to in Articles L. 1121-5, L. 1121-7 and L1121-8 of the Public Health Code.
- Persons deprived of their liberty by a judicial or administrative decision, persons subject to psychiatric care under articles L. 3212-1, L. 3213-1