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EUS RFA for Treatment of Pancreatic Ductal Adenocarcinoma (PDAC)

EUS RFA for Treatment of Pancreatic Ductal Adenocarcinoma (PDAC)

Recruiting
18 years and older
All
Phase 1
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Overview

This is a single arm study in the treatment of pancreatic ductal adenocarcinoma (PDAC). The investigators propose to test the tolerability of chemotherapy plus endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) using the RF Electrode in patients receiving palliative second or third line therapy for unresectable non-metastatic pancreatic cancer.

Eligibility

Inclusion Criteria:

  • Diagnosed and histologically confirmed PDAC by biopsy
  • Axial CT scan or MRI consistent with PDAC with at least 1 cm in greatest diameter
  • ECOG performance status 0-2
  • Patients with locally advanced PDAC, who have not responded or progressed on first line chemotherapy, are deemed not resectable based on multidisciplinary review, and show no evidence of distant metastasis
  • Lesions between 1 - 4cm in size

Exclusion Criteria:

  • Patients that show evidence of distant metastasis
  • Endoscopically non-accessible mass
  • Pregnant patients
  • Inability to provide informed consent
  • Lesions <1cm, or >4cm in greatest diameter

Study details
    Pancreatic Cancer

NCT05723107

NYU Langone Health

9 March 2024

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