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Prevalence of Hyponatremia in Dengue Infected Patients: Relationship With Systemic Inflammation.

Prevalence of Hyponatremia in Dengue Infected Patients: Relationship With Systemic Inflammation.

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Overview

Prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and November 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Description

Background Dengue infection is becoming more prevalent worldwide and is associated with systemic inflammation. Systemic Inflammation is associated with non-osmotic release of ADH.

Methods: Participants conducted a prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and November 1, 2023. Diagnosis was confirmed by IgM serology or PCR. Hyponatremia was defined as serum sodium concentration ≤135 mEq/L.

Eligibility

Inclusion Criteria:

  • Diagnosis confirmed by PCR, non structural protein 1 (NS1) antigen or IgM serology.

Plasma sodium at admission.

Exclusion Criteria:

  • None

Study details
    Hyponatremia
    Dengue
    Inflammation

NCT06109532

Hospital Nacional Profesor Alejandro Posadas

14 October 2025

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