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Efficacy and Safety of Triple Therapy in Patients With Anti-MDA5 Antibody-positive Dermatomyositis

Efficacy and Safety of Triple Therapy in Patients With Anti-MDA5 Antibody-positive Dermatomyositis

Non Recruiting
18 years and older
All
Phase 4
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Overview

We conduct this study to investigate the efficacy of triple therapy (high-dose glucocorticoids + cyclophosphamide + calcineurin inhibitor) compared with dual-therapy regimens (high-dose glucocorticoids + cyclophosphamide/calcineurin inhibitor) and whether it reduces the risk of poor pulmonary prognosis in patients with moderate to high risk anti-MDA5+ DM.

Eligibility

Inclusion Criteria:

  • Adult patients meet the diagnostic criteria for dermatomyositis of Bohan and Peter
  • Anti-MDA5 Antibody-positive

Exclusion Criteria:

  • Complicated with other connective tissue diseases
  • Complicated with cardiovascular and respiratory disease caused by other reasons
  • Interstitial lung disease caused by environment and drugs
  • Patients with key research missing data or without informed consent

Study details
    Dermatomyositis
    Adult Type
    Interstitial Lung Disease

NCT05375435

The First Affiliated Hospital with Nanjing Medical University

20 August 2025

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