Overview

This study is a dynamically adjustable prospective longitudinal study designed to capture biospecimen (biopsy, blood, surgical) and multimodal treatment (imaging, dosimetry, clinical) data before, during, and after treatment with definitive-intent standard of care (SOC) radiotherapy for patients with locally advanced cervical and pancreatic cancer.

Eligibility

Inclusion Criteria:

• Confirmation of intent to receive standard of care radiotherapy for one of the following diagnoses:
  • Locally advanced or metastatic cervical cancer
  • Locally advanced or metastatic pancreatic cancer
• ECOG performance status ≤ 2
• At least 18 years old
• Able to understand and willing to sign an IRB-approved written informed consent document

Exclusion Criteria:

• Co-enrollment to another therapeutic study receiving investigational agent
• Any issue (medical, anatomic, other) that might preclude safe acquisition of biospecimens at the discretion of the treating physician