Overview

An open label, randomized study of neoadjuvant nivolumab and chemotherapy, with or without sub-ablative stereotactic body radiation therapy, for resectable stage IIA to IIIB non-small cell lung cancer

Eligibility

Inclusion Criteria:

1. Patient has histologically or cytologically proven clinical stages IIA (tumors > 4 cm), IIB, IIIA, and IIIB (T3 or T4, N2) NSCLC (AJCC version 8) and is considered eligible for surgical resection with curative intent. Patients with 2 primary non-small cell lung cancers are allowed.
2. Measurable disease, as defined by RECIST v1.1.
3. Parenchymal lung tumor deemed to be amenable to treatment with sub-ablative stereotactic body radiation therapy, as determined by a co-investigator from Radiation Oncology
4. Written informed consent and Health Insurance Portability and Accountability Act (HIPAA) obtained from the subject prior to performing any protocol-related procedures.
5. Age > 18 years at time of study entry
6. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
7. Adequate normal organ and marrow function as defined below:
   • Hemoglobin ≥ 9.0 g/dL
   • Absolute neutrophil count (ANC) ≥ 1.5 x 109/L (> 1500 per mm3)
   • Platelet count ≥ 100 x 109/L (>100,000 per mm3)
   • Serum bilirubin ≤ 1.5 x institutional upper limit of normal (ULN). This will not apply to subjects with confirmed Gilbert's syndrome (persistent or recurrent hyperbilirubinemia that is predominantly unconjugated in the absence of hemolysis or hepatic pathology), who will be allowed only in consultation with their physician.
   • Aspartate aminotransferase (SGOT)/Alanine Aminotransferase (SGPT), and alkaline phosphatase ≤ 2.5 x institutional upper limit of normal (ULN).
   • Serum creatinine clearance>50 mL/min by the Cockcroft-Gault formula (Cockcroft and Gault 1976) or by 24-hour urine collection for determination of creatinine clearance (CL):

     Males

Creatinine CL (mL/min)

• Weight (kg) x (140 - Age) . 72 x serum creatinine (mg/dL)

  Females

Creatinine CL (mL/min)

• Weight (kg) x (140 - Age) x 0.85 72 x serum creatinine (mg/dL) 8. Evidence of post-menopausal status or negative urinary or serum pregnancy test for

  female pre-menopausal patients. Women will be considered post-menopausal if they have been amenorrheic for 12 months without an alternative medical cause. The following age-specific requirements apply:

             Women <50 years of age would be considered post-menopausal if they have been
             amenorrheic for 12 months or more following cessation of exogenous hormonal treatments
             and if they have luteinizing hormone and follicle-stimulating hormone levels in the
             post-menopausal range for the institution or underwent surgical sterilization
             (bilateral oophorectomy or hysterectomy).
             Women ≥50 years of age would be considered post-menopausal if they have been
             amenorrheic for 12 months or more following cessation of all exogenous hormonal
             treatments, had radiation-induced menopause with last menses >1 year ago, had
             chemotherapy-induced menopause with last menses >1 year ago, or underwent surgical
             sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy).
          9. Subject is willing and able to comply with the protocol for the duration of the study
             including undergoing treatment and scheduled visits and examinations including follow
             up.
         10. No prior therapy for their lung cancer.
        Exclusion Criteria:
        Subjects should not enter the study if any of the following exclusion criteria are
        fulfilled:
          1. Participation in another clinical study with an investigational product during the
             last 3 weeks.
          2. Active other primary malignancy excepting:
               -  Malignancy treated with curative intent and with no known active disease and of
                  low potential risk for recurrence.
               -  Adequately treated non-melanoma skin cancer or lentigo maligna without evidence
                  of disease.
               -  Adequately treated carcinoma in situ without evidence of disease eg, cervical
                  cancer in situ, in-situ urinary bladder cancer, treated localized prostate cancer
                  and ductal carcinoma-in situ.
          3. Current or prior use of immunosuppressive medication within 14 days before the first
             dose of nivolumab, with the exceptions of intranasal, inhaled, topical steroids, or
             local steroid injections (e.g., intra articular injection), corticosteroids or
             systemic corticosteroids at physiological doses, which are not to exceed 10 mg/day of
             prednisone, or an equivalent corticosteroid, and steroids as premedication for
             hypersensitivity reactions (e.g., CT scan premedication).
          4. Patients with Grade ≥2 neuropathy.
          5. Previous receipt of immunotherapy.
          6. Active or prior documented autoimmune or inflammatory disorders that has required
             systemic treatment in the past year (including inflammatory bowel disease [e.g.,
             colitis or Crohn's disease systemic lupus erythematosus, Sarcoidosis syndrome, or
             Wegener syndrome [granulomatosis with polyangiitis, Graves' disease, rheumatoid
             arthritis, hypophysitis, uveitis, etc]). No active diverticulitis within the previous
             3 months. The following are exceptions to this criterion:
               -  Patients with vitiligo or alopecia
               -  Patients with hypothyroidism (e.g., following Hashimoto syndrome) stable on
                  hormone replacement
               -  Any chronic skin condition that does not require systemic therapy
               -  Patients without active disease in the last 5 years may be included but only
                  after consultation with the study physician
               -  Patients with celiac disease controlled by diet alone
          7. History of allogeneic organ transplant.
          8. History of hypersensitivity to nivolumab or any excipient.
          9. Uncontrolled intercurrent illness that would limit compliance with study requirements,
             substantially increase risk of incurring AEs or compromise the ability of the patient
             to give written informed consent.
         10. Active infection including tuberculosis (clinical evaluation that includes clinical
             history, physical examination and radiographic findings, and tuberculosis (TB) testing
             in line with local practice), active hepatitis B (known positive HBV surface antigen
             (HBsAg) result), active hepatitis C.
         11. Female patients who are pregnant or breastfeeding or male or female patients of
             reproductive potential who are not willing to employ effective birth control from
             screening to 90 days after the last dose of nivolumab monotherapy.
         12. History of interstitial lung disease, idiopathic pulmonary fibrosis, pneumonitis
             (including drug induced), or evidence of active pneumonitis on screening chest CT
             scan.
         13. Receipt of the last dose of therapy (chemotherapy, immunotherapy, endocrine therapy,
             targeted therapy, biologic therapy, tumor embolization, monoclonal antibodies, or
             other investigational agent) for an accepted other malignancy as defined in Section
             3.3.2 within 30 days prior to the first dose of study drug for lung cancer.