Overview
The Nectin-4 protein belongs to the cell adhesion factors family and has a tissue-specific expression spectrum in normal human tissues. However, Nectin-4 is overexpressed in various malignancies, especially those of epithelial origins, such as uroepithelial carcinoma, making Nectin-4 a highly specific and significant imaging target for malignancies.
[68Ga]N188, a novel molecular probe of PET imaging agent that targets Nectin-4, can be used in the diagnosis and research of a wide variety of Nectin-4 high-expression malignancies, including bladder cancer.
Eligibility
Inclusion Criteria:
- patients with confirmed or suspected cancer;
- 18F-FDG PET/CT within 1 week;
- Signed written informed consent.
Exclusion Criteria:
- Pregnant and lactating women;
- Female patients plan to become pregnant within 6 months.