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Features of Regional Perfusion of Lung Consolidation

Recruiting
18 - 90 years of age
Both
Phase N/A

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Overview

The aim of this study is to evaluate the potential usefulness of lung ultrasound to assess the size and perfusion of consolidation and explore their relationships with clinical outcome.

Description

Lung consolidation is one of the most causes of hypoxia in intensive care unit(ICU) settings. A quantitative measurement of consolidation would be extremely benefit for the clinical management in hypoxemia, both as an index of severity and to predict outcomes.In order to quantify the lung consolidation and its effect on clinical outcomes, a simple and quantitative scoring system of the size and perfusion of lung consolidation was proposed by lung ultrasound. Subjects with respiratory failure and lung consolidation proved by chest imaging underwent lung ultrasound examination. The size of consolidation and the richness of blood flow was computed upon lung ultrasound. The sensitivity, specificity and accuracy of the scoring system were calculated and compared to evaluate the diagnostic efficacy.

Eligibility

Inclusion criteria:

  1. Admission to ICU( 18yr<age<90yr);
  2. Patients presented with acute respiratory failure;
  3. Pulmonary consolidation by chest imaging (lung ultrasound, X ray or CT scan).

Exclusion criteria:

  1. Hemodynamic instability (i.e., severe hypotension with systolic arterial pressure<60mmHg despite fluid expansion and vasoactive support; systolic arterial pressure>180mmHg; uncontrolled cardiac arrhythmias);
  2. Severe thoracic trauma;
  3. Coronavirus disease 2019;
  4. Pulmonary artery hypertension and pregnancy.

Study details

Lung Injury, Acute, Ultrasound Therapy; Complications

NCT05647967

Peking Union Medical College Hospital

26 January 2024

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