Overview
This study includes naive patients and csDMARDs-IR RA patients, treated with different regimens such as Iguratimod combination of different csDMARDs, or csDMARD with TNF inhibitors for 24 weeks. The disease activity and drug response will be observed. The immune disorder and synovial function will be evaluated at the same time.
Description
In this study cohorts, naïve or csDMARDs-IR patients are treated with different csDMARDs combination or TNF inhibitors for 24 weeks to get remission in clinical. The biomarkers in their plasma and synovial fluid and tissue specimens from RA patients are screened to predict the efficacy of specific treatment.
Eligibility
Inclusion Criteria:
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1.Patients with RA who meet ACR 1987 rheumatoid arthritis classification criteria or
ACR/EULAR 2010 rheumatoid arthritis Classification Criteria and have knee dysfunction.
1. ACR 1987 rheumatoid arthritis classification criteria
1. morning stiffness lasting at least 1 hour (≥6w)
2. there are 3 or more joint areas swollen (≥6w)
3. swelling of the wrist, metacarpophalangeal, and proximal phalangeal joint areas
(≥6w)
4. symmetrical arthrogryposis (≥6w)
5. hand x-ray changes (at least osteoporosis and joint space narrowing)
6. positive rheumatoid factor (titer > 1:32) RA can be diagnosed by meeting 4 of the
above 7 items
2. ACR/EULAR 2010 rheumatoid arthritis Classification Criteria
1. Involved joints
- 1 large joint (0 points)
- 2-10 large joints (1 point)
- 1-3 small joints (with or without large joints) (2 points)
- 4-10 small joints (with or without large joints) (3 points)
- more than 10 small joints (at least one small joint) (5 points)
2. Serological indicators
- RF and ACPA negative (0 points)
- RF and ACPA, at least one of which is low titer positive. (2 points)
- RF and ACPA with at least one high titer positive (3 points)
3. Acute chronotropic reactants
- Both CRP and ESR normal (0 points)
- Abnormal CRP or ESR (1 point)
4. Duration of synovitis
- <6 weeks (0 points)
- ≥6 weeks (1 point)
2.Patients with OA who meet the 1995 Classification Criteria for OA and have
knee dysfunction 1995 Classification Criteria for Osteoarthritis of the Knee
Clinical criteria
a. Knee pain most of the time in the last 1 month b. Bone rubbing sound c,
morning stiffness ≤ 30 minutes d, age ≥ 38 years e, with bony enlargement
Knee OA can be diagnosed if a+b+c+d or a+b+e is met
3.Age-sex matched healthy volunteers who checked in our hospital.
4.Age > 18 years old;
5.Voluntarily participate in this study and sign an informed consent form
Exclusion Criteria:
1. Patients with combined active hepatitis
2. Patients with active tuberculosis
3. Patients withinfection and malignancy