Overview
The purposes of this Phase 1 study of EDG-7500 are to:
- Learn about the safety of EDG-7500 after a single and multiple doses in healthy adults
- Learn about how EDG-7500 is tolerated after a single and multiples doses in healthy adults
- Evaluate the amount of EDG-7500 is in the blood and urine after single and multiple doses in healthy adults
- Evaluate the effect of a meal on the amount of EDG-7500 that is in the blood in healthy adults
- Evaluate whether the amount of EDG-7500 in the blood is similar for the suspension and tablet forms of EDG-7500 in healthy adults
Participants will receive a single or multiple doses of EDG-7500 or a placebo by mouth.
Eligibility
Inclusion Criteria:
- Willing and able to give informed consent and follow all study procedures and requirements.
- Healthy male or nonpregnant female, ages ≥ 18 to < 60 years.
- Body mass index (BMI) ≥ 18 to < 35 kg/m2; weight ≥ 55 kg at Screening.
- Absence of important health problems and essentially normal physical examination, normal laboratory screening tests, and normal electrocardiogram (ECG) with QTcF ≤ 450 ms.
Exclusion Criteria:
- Evidence of clinically significant abnormalities or disease.
- Unless permitted by protocol, use of any prescription medication ≤ 4 weeks or investigational medication ≤ 12 weeks or ≤ 5 half-lives (whichever is longer) of dosing. Use of any non-prescription medication or herbal/nutritional supplement ≤ 5 days prior to dosing.
- Donation or loss of > 1 unit (450 mL) of blood ≤ 1 month prior to dosing.
- Females: nursing, lactating, or pregnant.
- Females: breast implants.
- Use of nicotine-containing products in the last 6 months prior to dosing.
- History of substance abuse or dependency or history of recreational drug use. Alcohol consumption > 14 drinks per week for males (7 for females). Positive screen for drugs of abuse or alcohol or cotinine test at Screening or Admission.
Additional protocol defined inclusion/exclusion criteria may apply.