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Post-transplant PT/FLU+CY Promotes Unrelated Cord Blood Engraftment in Haplo-cord Setting in Childhood Leukemia

Recruiting
1 - 18 years of age
Both
Phase N/A
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Overview

To determine if the novel regimen of PT/FLU+CY promotes cord blood engraftment in children's leukemia HSCT cohort

Description

PTCy is a well-established haploidentical transplant regimen strategy. Moreover, unrelated cord blood (UCB) plays a critical role in the effects of GVL. However, the engraftment of grafts is unpredictable in the setting of a haplo-cord subsequent transplant. Therefore, applying a novel post-transplant regimen of PT/CY+FLU may selectively promote UCB engraftment in the setting of haplo-cord transplant.

Eligibility

Inclusion Criteria:

  • children acute leukemia

Exclusion Criteria:

  • MODS

Study details

Leukemia, Stem Cell Transplant, Cord Blood

NCT06155188

Nanfang Hospital, Southern Medical University

26 January 2024

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