Overview
the investigators aim to determine the effect of 4 weeks of frequent active breaks from prolonged sitting on time in target glycaemic range in people with type 1 diabetes with high habitual sedentary behaviour.
Description
An open-label randomised controlled trial, whereby participants will complete pre-randomisation baseline procedures before allocation to 4wks of habitual activity (control) or active breaks. Interstitial glucose concentrations (fGM), insulin dose and physical activity/ postural transitions (ActivPAL) will be monitored throughout. To improve generalisability and feasibility of recruiting the required number of participants, the study will be completed in a free-living environment using remote data collection methods.
Eligibility
Inclusion Criteria:
- T1D diagnosis more than 3 years ago
- Sedentary (> 10h per waking day sedentary (sitting or lying)
- Using insulin therapy with multiple daily injections or insulin pump
- Aged 18-66 (UK retirement age)
- Use of Abbot FreeStyle Libre 2 fGM (>6 weeks to avoid potential lifestyle changes as a result of sensor use)
Exclusion Criteria:
- Engaged in structured planned exercise (e.g. running, cycling, gym, or sports)
- Pregnancy or planning to become pregnant
- <6 months postpartum or stopped breastfeeding <1 month before recruitment
- Existing cerebrovascular or cardiovascular disease
- Significant history of hyperglycaemia (HbA1c >85 mmol/mol)
- History of severe hypoglycaemia requiring third party assistance within the last 3 months