Overview
Prospective, multi-centric, split-sample, sibling oocyte study evaluating the safety and efficacy of a new method to prepare sperm samples for IVF (in vitro fertilization) / ICSI (intracytoplasmic sperm injection) compared to standard procedures.
Eligibility
- Female
Inclusion Criteria:
- With ovarian reserve of between 8 and 30 antral follicles counting both ovaries
- Treatment planned for embryo transfer at the blastocyst stage
Exclusion Criteria:
- Any diagnosed sexually transmitted infection (STI)
- Diabetes or other metabolic disorders.
- Recurrent pregnancy loss (defined as >2 clinical pregnancies without live birth).
- Previous failures in two or more IVF cycles
- Male
Inclusion Criteria for IVF:
- Age: 20-55 years
- Fresh sample (not cryopreserved )
- Sperm motility (TOTAL) ≥ 40% in spermogram
- Normal sperm morphology (Kruger criteria) ≥ 4% in spermogram
- Sperm count after swim up ≥ 5x10^6
- Treatment planned for embryo transfer at the blastocyst stage
Inclusion Criteria for ICSI:
- Age: 20-55 years
- Fresh sample (not cryopreserved )
- Sperm concentration ≥ 10x10^6 /ml in spermogram
- Sperm motility (TOTAL) ≥ 20% in spermogram
- Normal sperm morphology (Kruger criteria) ≥ 3% in spermogram
- Treatment planned for embryo transfer at the blastocyst stage
Exclusion Criteria:
- Any diagnosed sexually transmitted infection (STI)
- Total failure of in vitro fertilization in previous cycles.