Overview
To date, the radiation oncologist are missing biomarkers predictive of response/resistance to RT in order to identify patients who may benefit from RT and personalize the RT schedule. Our proposal is to conduct a cohort study aiming at identifying transcriptomic biomarkers predictive of sensitivity and/or resistance to RT in limbs STS patients
Description
Whether RT should be performed pre or post-operatively is still a debated question. To date, the radiation oncologist are missing signature of response/resistance to RT in order to identify patients who may benefit from RT and personalize the RT schedule. Therefore, predicting the likelihood of response/resistance to RT is essential. The individual exploration with high-throughput approaches will participate in describing biological mechanisms involved in STS tumor cell pan-resistance, thus identifying potential molecular targets that could be inhibited to reverse intrinsic radioresistance. In this context, our proposal is to conduct a cohort study aiming at identifying transcriptomic signature predictive of sensitivity and/or resistance to RT in limbs STS patients.
Eligibility
Inclusion Criteria:
- Male and female ≥ 18 years at time of non-opposition to participate to the study
- Patient with documented non-opposition to participate to the study.
- Patient with histologically and cytologically confirmed diagnosis with STS (..)
- Patient with availability of FFPE tumor block from initial diagnosis biopsy (mandatory) and surgery specimen (optional).
- Patients with tumor FFPE samples prepared with the last 4 years
- Patient with evaluable tumor sample meeting the following quality/quantity control criteria (..)
Exclusion Criteria:
- Patients with metastatic soft tissue sarcoma at diagnosis
- Patients with exclusive radiotherapy without surgical resection
- Patients receiving neo adjuvant systemic treatment (chemotherapy, immunotherapy, targeted therapy)