Overview
Critically ill patients are at risk of developing a sudden decrease of kidney function which may be detected by a decrease in urine output or is diagnosed on the basis of blood tests for substances normally eliminated by the kidney, primarily creatinine.
Because it takes about 24 hours for the creatinine level to rise, even if both kidneys have ceased to function, better markers are needed.
This trial is investigating if the marker urinary dickkopf-3 (uDKK3) allows an early prediction of a sudden decrease of kidney function.
Description
Urinary dickkopf-3 (uDKK3), a stress-induced renal tubular epithelium-derived glycoprotein, has been identified as a biomarker predicting persistent kidney dysfunction.
In this prospective observational trial in patients at high risk of developing acute kidney injury we will assess whether urinary dickkopf-3 serves as a predictor of acute kidney injury.
Patients of the intensive care units of Saarland University Hospital will be surveyed for up to two years after their admission to the intensive care unit.
The progression of the estimated Glomerular Filtration Rate and uDKK3 will be monitored.
Eligibility
Inclusion Criteria:
- Patients treated on the intensive care units of Saarland University Hospital.
Exclusion Criteria:
- Patients on renal replacement treatment before admission to the intensive care unit.
- Patients with chronic kidney disease stage CKD G3b or below.
- Known kidney disease.
- Kidney transplantation.
- Intoxications leading to dialysis treatment.
- Participation in other clinical trials.