Overview

The main goal of this study is to investigate the neural mechanisms of working memory function in patients with early psychosis using Transcranial Magnetic Stimulation (TMS) in conjunction with functional MRI. TMS is a noninvasive method used to modulate brain activity via changing magnetic fields applied over the surface of the scalp.

Eligibility

Inclusion Criteria:

• Diagnosis of psychosis, psychosis not otherwise specified, schizophrenia, schizoaffective disorder, delusional disorder, bipolar disorder with psychosis, and schizophreniform disorder within first ten years of onset of psychotic symptoms.
• Ability to provide informed consent

Exclusion Criteria:

• TMS incompatibility including metallic implants in head and neck, cardiac pacemakers, history of seizures, pregnancy.
• MRI-incompatibility including implanted aneurism clips, cardiac pacemakers, metal implants, intrauterine devices, tattoos containing metal ink, pregnancy, and claustrophobia
• Severe substance abuse within 3 months (nicotine allowed)
• Unstable medical or neurologic illness that would preclude participation in study procedures