Overview
The principal aim is to analyze total left and right ventricular activation time in different CRT device programming algorithms (SyncAV) measured by non-invasive electrophysiology
Description
Patient specific anatomic parameters taken from the cardiac magnetic resonance examination will be the base for a semiautomatic model incorporating the conductivity of the heart, the lungs, blood and the torso. For this reason, a software package (AMIRA Developer, TGS Template Graphics Software, France) has been adapted to calculate a quasi static approximation of Maxwell equations.
After fusion of the T1 CMR scan and the ECG electrodes a model-based bidomain FEM is used for a step-wise measurement of the local activation times (resting potential: 290 mV; plateau: 0 mV; acceleration time: 3 ms) both Ende- and epicardially.
Eligibility
Inclusion Criteria:
- patients after successful implantation of a CRT-D or CRT-P device in whom a cardiac magnetic resonance examination is possible and the device is equipped with the SyncAV® programming software
- left bundle branch block before CRT implantation
- PQ interval ≤ 250 ms before implantation
Exclusion Criteria:
- high-grade AV block
- any contraindication concerning a safe CMR performance including claustrophobia
- terminal heart failure (NYHA IV) or cardiac decompensation
- life expectancy < 1 year
- women with child-bearing potential, pregnancy
- drug abusus