Overview
This study will analyze gene expression and other laboratory data from biological samples collected from participants with suspected respiratory, urinary, intra-abdominal, and/or skin & soft tissue infections; or suspected sepsis of any cause.
Eligibility
Inclusion Criteria:
- Age >18 year
- Suspected acute infection (respiratory, urinary, abdominal, skin & soft-tissue), and
at least one of the symptoms OR, Suspected sepsis of any cause as defined by a blood
culture order by the treating physician, and at least two of the symptoms:
- Heart rate: >90 beats/ minute
- Temperature: >38 C or <36C
- Respiratory Rate: >20 breaths / minutes or PaO2 of <60 mmHg or SpO2 <90%
- Systolic blood pressure: <100 mmHg
- Altered mental status: Per clinical exam
- Able to provide informed consent, or consent by legally authorized representative.
Exclusion Criteria:
- Patient-reported treatment with systemic antibiotics, systemic antiviral agents, or
systemic antifungal agents within the past 7 days prior to the emergency department
study visit. Participants will not be excluded for the following:
- Use of topical antibiotics, topical antiviral or topical antifungal agents
- Use of peri-operative (prophylactic) antibiotics
- Use of a single dose of antibiotics during the present ED visit (<6h before blood draw).
- Prisoners, mentally disabled, or unable to give consent. Should the patient not be
able to provide informed consent the legally authorized representative can provide the consent on behalf of the patient.
- Previously enrolled in the present clinical trial.