Overview
The main objective of this prospective cohort study is to assess arrhythmia burden and glycemic variability in a multicenter cohort of patients with end-stage renal disease using a sufficient observation period in order to identify arrhythmia burden and type and characterize associations with patient characteristics and dialysis treatment, glycemic variability and subsequent risk of adverse outcomes.
Description
Background: The risk of dying of a cardiovascular disease is 10-20 times increased in patients dependent on dialysis treatment compared to the general population. 1/3 of these deaths is caused by arrhythmia and 'sudden cardiac death'.
Purpose: Investigate the prevalence and type of arrhythmia in patients dependent on dialysis treatment, including the association with patient- and dialysis related factors and cardiovascular outcomes.
Methods: 7-days Holter-monitoring with Cortrium C3+ holter-monitor in 540 patients dependent on dialysis treatment in the Capital Region of Denmark. Continous blood glucose monitoring in a subgroup. 1-year follow-up via national registers.
- Endpoints
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- Prevalence of atrial fibrillation
- Prevalence of other arrhythmia (tachycardia, bradycardia, AV-block)
- Follow-up outcomes: sudden cardiac death, cardiovascular disease and cardiovascular death
Eligibility
Inclusion Criteria:
- Dialysis-treated end-stage renal disease
- Age ≥ 18 years
- Competence to understand the study rationale necessary for written informed consent
Exclusion Criteria:
- Pre-existing pacemaker implantation