Overview
This is a multicenter, open label clinical trial evaluating the safety of the combination of belantamab mafodotin + the combination treatment VRd (bortezomib, lenalidomide, dexamethasone) in newly diagnosed (ND) transplant eligible multiple myeloma (MM) patients.
Eligible patients will be included in the study and they will receive three induction cycles with belantamab mafodotin (8-week cycles) and six induction cycles with VRd (4-week cycles). Immediately after the fourth VRd cycle, and in the absence of progression or unacceptable toxicity, mobilization of hematopoietic stem cells with G-CSF and subsequent apheresis will take place. Then, patients will receive one additional induction cycle with belantamab mafodotin (8-week cycle) and two additional induction cycles with VRd (4-week cycles) followed by intensification with high-dose melphalan (200mg/m2) and the autologous stem cell transplant. Three months after transplantation, and as long as clinical and hematological conditions allow, patients will receive one cycle of consolidation with belantamab mafodotin (8-week cycle) and two additional cycles of consolidation with VRd (4-week cycles) at the same doses as during induction and, subsequently, patients will receive maintenance treatment with lenalidomide (continuously until disease progression, patient withdrawal, unacceptable toxicity, loss to follow up, end of study or death) and belantamab mafodotin (for 2 years).
Description
This is a multicenter, open label clinical trial evaluating the safety of the combination of belantamab mafodotin + the combination treatment VRd (bortezomib, lenalidomide, dexamethasone) in newly diagnosed (ND) transplant eligible multiple myeloma (MM) patients.
The study comprise the following phases:
Induction: Cycles 1-6
Cycles will be of 8 weeks of duration for belantamab mafodotin and 28 days of duration for
- VRd
-
- Belantamab mafodotin will be administered at the dose of 2.5 mg/kg/every 8 weeks on day 1, intravenously.
- Bortezomib will be given subcutaneously, at 1.3 mg/m2, on days: 1, 4, 8 and 11 of every 28-day cycle.
- Lenalidomide will be given as an oral drug, in the dose of 25 mg/day on days 1-21.
- Dexamethasone will be given as an oral drug, in the dose of 20 mg on days: 1, 2, 4, 5, 8, 9, 11 and 12.
Peripheral stem cell harvest will be performed after the fourth cycle of treatment to prevent mobilization failure.
Intensification with high-dose melphalan (200 mg/m2) and autologous stem cell transplant (ASCT) will be performed as per routine practice. Mobilization of hematopoietic stem cells (HSCs) will be carried out using high-dose G-CSF after the fourth induction cycle with VRd. The dose of G-CSF used will be at the discretion of each site according to the local rules. Apheresis will be initiated on day 4-5 of stimulation, once the number of CD34+ cells in peripheral blood have reached the minimum to proceed with the collection. The minimum number of CD34+ cells needed to carry out the transplant will be determined at the discretion of each site, although a minimum of 2 x106 CD34+/Kg is recommended, as well as cryopreservation, storage, defrosting and infusion of HSCs. If mobilization fails using G-CSF alone, the recommended action is to utilize plerixafor during the same procedure in order to save this time. Sites should administer plerixafor in accordance with their own established procedures. If this second attempt fails, the site can proceed to a third mobilization attempt using cyclophosphamide plus G-CSF.
Consolidation: Cycles 6-8
At day +90, after autologous stem cell transplant patients will receive consolidation treatment with 1 additional cycle of belantamab mafodotin + 2 additional cycles of VRd following the same scheme as in the induction:
- Belantamab mafodotin will be administered at the dose of 2.5 mg/kg/every 8 weeks on day 1, intravenously.
- Bortezomib will be given subcutaneously, at 1.3 mg/m2, on days: 1, 4, 8 and 11 of every 28-day cycle.
- Lenalidomide will be given as an oral drug, in the dose of 25 mg/day on days 1-21.
- Dexamethasone will be given as an oral drug, at the dose of 20 mg on days: 1, 2, 4, 5,
8, 9, 11 and 12 of every 28-day cycle.
- Maintenance
After completion of the consolidation treatment, all the responding patients will receive maintenance treatment with Lenalidomide (10 mg/day) + belantamab mafodotin (2.5 mg/kg/every 8 weeks, intravenously). Lenalidomide will be administered continuously until disease progression, patient withdrawal, unacceptable toxicity loss to follow up, end of study or death. Belantamab mafodotin will be administered for 2 years until disease progression, patient withdrawal, loss to follow up, unacceptable toxicity, end of study or death.
The trial has the following objectives:
- Objectives
Primary objective
● To evaluate the safety and tolerability of the combination of belantamab mafodotin + VRd in newly diagnosed transplant eligible multiple myeloma patients.
Secondary objectives ● To assess the efficacy of belantamab mafodotin in combination with VRd in terms of response rate focusing on complete response and MRD.
• Efficiency of hematopoietic stem cell collection after 2 induction cycles of treatment of belantamab mafodotin + 4 induction cycles of treatment of VRd.
Eligibility
Inclusion Criteria:
- Participant must have Newly diagnosed multiple myeloma. Newly diagnosed subjects must have symptomatic disease following the IMWG updated criteria (Rajkumar Lancet 2014, Appendix 6).
- Participant must have a measurable secretory disease defined as either serum monoclonal protein of ≥ 0,5 g/dl or urine monoclonal (light chain) protein ≥ 200mg/24h.For patients whose disease is only measurable by serum FLC, the involved FLC should be ≥ 10mg/L (100 mg/dl), with an abnormal serum FLC ratio.
- Newly diagnosed participants must be eligible for stem cell transplant at investigator criteria.
- Participant must have an Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2
- Participant must be ≥ 18 years of age
- Participant must have adequate organ function, defined as follows:
System Laboratory Values Hematologic Absolute neutrophil count (ANC) ≥1.5 X 109/L Hemoglobin ≥8.0 g/dL Platelets ≥75 x 109/L for subjects in whom <50% of bone marrow nucleated cells are plasma cells; otherwise platelet count >50 × 109/L Calcium corrected serum calcium <14 mg/dL (<3.5 mmol/L); or free ionized calcium <6.5 mg/dL (<1.6 mmol/L); Hepatic Total bilirubin ≤1.5X ULN (Isolated bilirubin ≥1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin <35%) ALT ≤2.5 X ULN AST ≤2.5 X ULN Renal eGFRa ≥30 mL/min/ 1.73 m2 Spot urine (albumin/creatinine ratios (spot urine) <500 mg/g (56 mg/mmol)
- Female participants: contraceptive use should be consistent with local regulations
regarding the methods of contraception for those participating in clinical studies.
A female participant is eligible to participate if she is not pregnant or breastfeeding, and at least one of the following conditions applies:
- Is not a woman of childbearing potential (WOCBP) OR
- Is a WOCBP and using a contraceptive method that is highly effective (with a failure rate of <1% per year), preferably with low user dependency, during the intervention period and for at least 4 months after the last dose of study intervention and agrees not to donate eggs (ova, oocytes) for the purpose of reproduction during this period. The investigator should evaluate the effectiveness of the contraceptive method in relationship to the first dose of study intervention.
A WOCBP must have a negative highly sensitive serum pregnancy test (as required by
local regulations) within 72 hours before the first dose of study intervention and
agree to use a highly effective method of contraception during the study and for 4
months after the last dose of belantamab mafodotin. Additional requirements for
pregnancy testing during and after study intervention The investigator is responsible
for review of medical history, menstrual history, and recent sexual activity to
decrease the risk for inclusion of a woman with a nearly undetected pregnancy.
Nonchildbearing potential is defined as follows (by other than medical reasons):
- ≥45 years of age and has not had menses for >1 year
- Patients who have been amenorrhoeic for <2 years without history of a
hysterectomy and oophorectomy must have a follicle stimulating hormone value in
the postmenopausal range upon screening evaluation Post-hysterectomy,
post-bilateral oophorectomy, or post-tubal ligation. Documented hysterectomy or
oophorectomy must be confirmed with medical records of the actual procedure or
confirmed by an ultrasound. Tubal ligation must be confirmed with medical records
of the actual procedure.
8. Male participants: contraceptive use should be consistent with local regulations
regarding the methods of contraception for those participating in clinical studies.
Male participants are eligible to participate if they agree to the following during
the intervention period and for at least 6 months:
- Refrain from donating sperm
PLUS either:
- Be abstinent from heterosexual intercourse as their preferred and usual lifestyle
(abstinent on a long term and persistent basis) and agree to remain abstinent. OR
- Must agree to use contraception/barrier as detailed below:
Agree to use a male condom and female partner to use an additional highly effective
contraceptive method with a failure rate of <1% per year as when having sexual
intercourse with a woman of childbearing potential (including pregnant females). All
prior treatment-related toxicities (defined by National Cancer Institute- Common
Toxicity Criteria for Adverse Events (NCI-CTCAE), version 4.0 (must be ≤ Grade 1 at
the time of enrolment except for alopecia).
9. Participant must be able to understand the study procedures and agree to participate
in the study by providing written informed consent.
Exclusion Criteria:
Patients that present any of the following exclusion criteria cannot be included in the
trial:
1. Participant has a diagnosis of primary amyloidosis, monoclonal gammopathy of
undetermined significance (MGUS), smoldering multiple myeloma (SMM), plasma cell
leukemia or active POEMS syndrome at the time of screening.
2. Participant has malignancies other than disease under study, except for any other
malignancy from which the participant has been disease-free for more than 2 years and,
in the opinion of the principal investigators, will not affect the evaluation of the
effects of this clinical trial treatment on the currently targeted malignancy.
Participants with curatively treated non-melanoma skin cancer may be enrolled.
3. Participant has meningeal involvement of multiple myeloma.
4. Pregnant or breastfeeding females.
5. Participant is simultaneously enrolled in other interventional clinical trial.
6. Participant must has used an investigational drug within 14 days or five half-lives,
whichever is shorter, preceding the first dose of study drug.
7. Participant has used of any anti-myeloma drug therapy, except for steroid pulses in
case of emergency (40 mg of dexamethasone for 4 days), the administration of
bisphosphonates or antialgic radiotherapy or due to the presence of plasmacytomas
requiring some emergency.
8. Participant who have received prior treatment with a monoclonal antibody within 30
days of receiving the first dose of study drugs.
9. Participant has a known immediate or delayed hypersensitivity reaction or idiosyncrasy
to drugs chemically related to: belantamab mafodotin, lenalidomide, boronic acid
(bortezomib), dexamethasone or any of the components of the study treatment.
10. Participant who have had major surgery ≤ 4 weeks prior to initiating protocol therapy.
11. Participant who have current corneal epithelial disease except mild punctate
keratopathy
12. Participant has peripheral neuropathy or neuropathic pain grade ≥2, as defined by the
National Cancer Institute Terminology Criteria for Adverse Events (NCI CTCAE) Version
4.0 (APPENDIX 4).
13. Participant is unable or unwilling to undergone antithrombotic prophylactic treatment
14. Participant evidence of cardiovascular risk including any of the following:
- Evidence of current clinically significant uncontrolled arrhythmias, including
clinically significant ECG abnormalities such as 2nd degree (Type II) or 3rd
degree atrioventricular (AV) block.
- History of myocardial infarction, acute coronary syndromes (including unstable
angina), coronary angioplasty, or stenting or bypass grafting within three months
of Screening.
- Class III or IV heart failure as defined by the New York Heart Association
functional classification system [NYHA, 1994]
- Uncontrolled hypertension
15. Incidence of gastrointestinal disease that may significantly alter the absorption of
Lenalidomide.
16. Participant must not have current unstable liver or biliary disease defined by the
presence of ascites, encephalopathy, coagulopathy, hypoalbuminemia, esophageal or
gastric varices, persistent jaundice, or cirrhosis. Note: Stable chronic liver disease
(including Gilbert's syndrome or asymptomatic gallstones) or hepatobiliary involvement
of malignancy is acceptable if otherwise meets entry criteria
17. Presence of active renal condition (infection, requirement for dialysis or any other
condition that could affect patient's safety). Participants with isolated proteinuria
resulting from MM are eligible, provided they fulfil inclusion criteria
18. Participant who use contact lenses while participating in this study, except if
contact lenses are removed during participation in the study
19. Participant who have had plasmapheresis within 7 days prior to first dose of study
treatment.
20. Evidence of active mucosal or internal bleeding.
21. Any serious medical condition or psychiatric illness that would interfere in
understanding of the informed consent form.
22. Uncontrolled endocrine diseases (i.e. diabetes mellitus, hypothyroidism or
hyperthyroidism) (i.e. requiring relevant changes in medication within the last month,
or hospital admission within the last 3 months).
23. Patients with acute diffuse infiltrative pulmonary disease and/or pericardial disease.
24. Patients with severe chronic obstructive pulmonary disease (COPD) or asthma with
forced expiratory volume in the first minute (FEV1) less than 50%.
25. The subject is seropositive for human immunodeficiency virus (HIV) or presence of
active hepatitis B infection (documented by a positive test for hepatitis B surface
antigen [HBsAg], or hepatitis C (documented by a positive test for the surface antigen
of hepatitis C [HCsAg] or positive quantification of HCV RNA Note: Participants with
positive Hepatitis C antibody due to prior resolved disease can be enrolled, only if a
confirmatory negative Hepatitis C RNA test is obtained.
Note: Hepatitis RNA testing is optional and participants with negative Hepatitis C antibody
test are not required to also undergo Hepatitis C RNA testing.