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Stimulation of the Larynx to Treat Unexplained Chronic Cough

Stimulation of the Larynx to Treat Unexplained Chronic Cough

Recruiting
18-88 years
All
Phase N/A

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Overview

Researchers will test the effect of non-invasive vibrotactile stimulation of the larynx on symptom severity of unexplained chronic cough.

Eligibility

Inclusion Criteria:

  • Adults aged 18-88
  • >8 weeks of cough
  • Cough visual analogue scale (VAS): Rating of 30 or greater on a 0-100 cough severity scale
  • Ability to provide informed consent and independently complete questionnaires
  • Ability to read and speak English

Exclusion Criteria:

  • Electronic implants (e.g., pacemaker)
  • Currently doing speech therapy for cough
  • Contraindications to safe or effective VTS device use
  • No regular access to wifi internet Neuromuscular impairment that may affect cough/laryngeal sensation and/or function (e.g., multiple system atrophy, Parkinson, CVA, vocal fold paralysis or paresis)
  • Untreated carotid disease
  • BMI > 40 (for transmission of VTS through soft tissue)
  • Current or recent (quit < 3 months ago) smoking
  • Known currently infectious cause for cough (e.g., TB, pertussis, COVID)
  • History of known or suspected aspiration pneumonia
  • Diagnosis or clinical suspicion of chronic obstructive pulmonary disease (COPD)
  • Diagnosis or clinical suspicion of interstitial lung disease (ILD)
  • Unmanaged reflux
  • Unmanaged allergies/postnasal drip

Study details
    Cough

NCT05273190

University of Minnesota

6 May 2025

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