Overview
Arterial spin labeling (ASL) is a non-invasive MRI technique that could help the radiologists to distinguish brain metastasis progression versus radionecrosis following gamma-knife treatment.
The primary target of the study is to establish the diagnostic performances (specificity, sensitivity) of quantitative measures of ASL in brain metastases suspected of progression/radionecrosis after GK treatment
Description
The metastasis progression versus radionecrosis following GK treatment can sometimes be difficult to distinguish. 60 patients will be included in this prospective, monocentric study. 3 MRI (baseline, 1month and 6 month follow-ups) will be performed. Two neuroradiologists will blindly analyse the MRIs comparing ASL sensibility and specificity to the standard morphological evaluation and T2 perfusion.
Eligibility
Inclusion Criteria:
- Brain metastasis from histologically proven tumor
- GK treatment within 4 month prior to the inclusion
- Lesions suspected of progression/ radionecrosis :
i.e.≥ 25% of the size progression
- Lesion size: gadolinium enhanced part of the tumour ≥1 cm
Exclusion Criteria:
- Pregnancy
- Medical history of primitive brain tumour
- MRI incompatibility/ medical history of contrast agent allergy
- Claustrophobia
- Patient unable to consent
- Epilepsia/recent stroke
- Patients participating in other studies
- Patients without health care insurance