Overview

This study is a multi-center, prospective, self-controlled study, to evaluate the feasibility of targeted axillary lymph node resection (TAD) guided by tissue marker clip with methylene blue single tracer after neoadjuvant chemotherapy in T1-4N1M0 breast cancer patients. Evaluate the accuracy and false negative rate of TAD, comparing with sentinel lymph node biopsy, and explore a new axillary-preserving mode after neoadjuvant chemotherapy for breast cancer.

Eligibility

Inclusion Criteria:

1. breast cancer with axillary lymph node metastasis confirmed by puncture pathology (T1-3N1M0)
2. accord with the indications of neoadjuvant chemotherapy for breast cancer
3. informed consent has been signed
4. Preoperative anesthesia assessment is low to medium risk (ASA score)

Exclusion Criteria:

1. There are absolute and relative contraindications of chemotherapy
2. Refuse surgery or can't tolerate surgery
3. Unable to cooperate or unwilling to place Marker
4. Pregnant women
5. Do not have full capacity for behavior, such as mental patients, drug dependence, anxiety and so on
6. Diabetes patients who are difficult to control
7. Excessive smokers
8. high risk of anesthesia
9. Any serious complications are not suitable for patients participating in this study