Overview
The purpose of this research is to evaluate how to manage the axillary lymph nodes in patients with breast cancer. The investigators will determine if a sampling of the lymph nodes under the arm will give the information necessary to determine if fewer lymph nodes can be removed.
Eligibility
Inclusion Criteria:
- Women or men greater than or equal to 18 years.
- Histologically confirmed invasive adenocarcinoma of the breast.
- Clinical T0-4 N2-3 M0 at diagnosis (American Joint Committee on Cancer, 7th Edition)
- Assessment for cN2 disease will be performed by clinical exam and imaging. Patients should have pathologic level 1 and/or 2 axillary lymph nodes which are fixed/matted on physical exam.
- Cross-sectional imaging will be used to identify advanced nodal disease involving the axilla, infraclavicular, supraclavicular, and internal mammary regions, cN3 disease.
- Patients must have biopsy proven involvement of the axillary lymph nodes.
- Receipt of standard multiagent chemotherapy +/- targeted therapy based on tumor subtype.
- Candidate for surgical management of breast cancer.
- Ability to understand and willingness to sign a written informed consent document.
Exclusion Criteria:
- History of allergic reactions or hypersensitivity to radioactive lymph node mapping agents or blue dye.
- Pregnancy.